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Mitotane is an antineoplastic medication known commercially as Lisodren.
This medication for oral use is indicated for the treatment of kidney cancer, since it has a direct effect on the adrenal gland.
Mitotane Indications
Kidney cancer; Cushing's syndrome.
Mitotane Price
A box of 500 mg containing 100 tablets costs approximately 1,200 reais.
Side Effects of Mitotane
Lethargy; somnolence; dizziness; vertigo; skin toxicity; lack of appetite; nausea; vomiting; diarrhea.
Contraindications for Mitotane
Pregnancy Risk C; lactating women; Hipersensibility to any of the formula's components.
How to Use Mitotane
Oral use
Adults
- Kidney cancer (inoperable): Start treatment with administration of 1 to 6 g per day, divided into 3 or 4 doses. Increase to 9 to 10 g per day, if there is a good clinical response. If serious adverse reactions appear, reduce the dose to the maximum that is tolerated. The maximum daily dose indicated is 2 to 16 g. If no clinical benefits are observed after 3 months of treatment, at the maximum dose indicated, it is possible that the patient will not benefit from continuing treatment.
- Cushing's Syndrome: Start treatment with administration of 1 to 12 g per day, in divided doses. The maintenance dose is between 500 mg (twice a week) to 2 g per day for 3 months.
Created by: Tua Saúde Editorial Team